What do Electrosensitivity (ES). Chronic Fatique Syndrome (CFS), Mutilple Chemical Sensitivity (MCS), Fibromyalgia (FM), Post Traumatic Stress Disorder (PSTF), and other unexplained diseases have in common?
They share a common mechanism, called the NO/ONOO cycle, which provides long sought explanation of why these disorders and syndromes are so difficult to diagnosis, and in fact cannot even be officially classified as disease, because they present differently in different individuals and do not afford clinicians the ability to identify or treat them by means of a recognizable pattern of symptoms or lab test results.
Explaining Unexplained Illness, by Dr. Martin Pall, demonstrates, in over 400 pages of well organized molecular and biochemical discussion (with over 1500 references), that the weight of evidence points to electronic imbalances, which can be triggered by various stresses, such electromagnetic exposure, bacterial infections, environmental chemical stresses, emotional or mental stresses, all leading to a common clinical outcome by a common pathway, the NO/ONOO cycle (the nitric oxide peroxynitrite cycle).
The No! Oh No! Cycle in a Nutshell
Multi-system mystery illness can be initiated by even short-term stressors, and each of a very wide variety of stressors is known to stimulate responses that raise the levels of nitric oxide (NO) and its oxidant product peroxynitrite (ONOO), which means any stressor can initiate the cycle in a common way and lead to elevated levels of these two compounds in the body. And once chronically elevated they act through known biochemical sequences, including inflammation and molecular fragmentation, to stay elevated. These elevation mechanisms constitute a cycle that is responsible for the chronic nature of these illnesses by creating a pathological state that propagates itself.
In other words, particular stressors (which are known to trigger unexplained illnesses even at short term exposure levels) such as infections, chemicals, and severe stress trigger increased levels of NO which then do not return to normal because NO triggers the production of harmful free radicals such as peroxynitrite, which the body is unable to deal with and lead to the various symptoms of these illnesses.
What symptoms present themselves in these multi-system illnesses, depends on where along the cycle the damage occurs, how long it has persisted, and how severe it is, leads to different symptoms in different people. Because these illnesses share multiple overlaps, they are referred to as multi-system illnesses.
Although this book was published in 2007 before Dr Pall’s similarly groundbreaking work on the effects of electromagnetic fields (EMF) on the the body’s own inherent electrical system, i.e. the voltage gated calcium channels (VGCC) of our cell membranes, he later found that the the parallels of electrosensitivity (ES) with these and other unexplained illness and their relation to the NO/ONOO cycle are notable. So, though each of these mysterious illnesses is initiated by different stressors (and different subsets of these stressors again for each individual), the self care methods for each of these unexplained illness would be the same. For example, ES is initiated by exposure to EMF (a particular source for each individual) and MCS is initiated by exposure to chemicals (a particular source for each individual), however the self care strategies for both begin with avoiding exposure to the (individual) stressor, and focusing healing efforts on breaking the NO/ONOO cycle by decreasing the production of nitric oxide.
Self Care Methods for Mystery Illness Sufferers
Chapter 15 begins telling us that the guiding principal for self-care of various mystery illness, such as ES, MCS, CF, PSTD, etc., is the use of agents that down-regulate NO/ONOO biochemistry, and the advice continues for 50 info-packed pages with specifics such as therapies, vitamins and supplements that have been found to be effective. Think antioxidants, Vitamin C, Coenzyme Q10, Carotenoids, Flavanoids, Glutathione, Lipoic Acid, Fish Oils, Curcumin, Chorella and all the good-for-you health minded supplements you can easily find on the shelf at Costco. And consider your food as nutritional therapy and make choices accordingly, consuming only nutrient dense foods.
Chapter 6, by contrast is a short 4 page chapter with a to-the-point message – Vitamin B12 is known to be the most potent nitric oxide scavenger, and has therefore been found to be helpful in lowering nitric oxide levels. The Hydroxocolblamin form of B12 is more effective in this regard than its precursor Cyancobalamin.
More in depth guidelines for nutritional self-care is found in the last chapter of the book and includes references to the work of:
- Dr Paul Cheney,
- Dr Jacob Teitelbaum,
- Dr Garth Nicolson,
- Dr Neboysa (Nash) Petrovic,
- Dr Grace Ziem,
- Dr Scott Rigden (AZ),
- Dr Gordon Baker (WA),
- Dr Sarah Myhill (UK),
- Dr Stepehn Levine,
All of these highly respected mystery illness professionals are easily searchable online and often their healing protocols are outlined in books they have written, or those of the patients they have helped.
My last thought was how vast the health, political and environmental implications were of Dr Pall’s work; a massive body of knowledge boldly daring to explain the growing number of unexplained illnesses that pervade our world, and are “a trillion dollar nightmare of human misery and bio-political inattention”, to quote Dr Paul Cheney.
And hitting an optimistic note of the hopeful visionary, Dr Jacob Teitelbaum, author of From Fatigued to Fantastic, calls this book “A brilliant treatise that brings us closer to a unified field theory, explaining underlying causes of poorly understood syndromes, bringing us closer to more effective treatment!”
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